反应详情

Potassium tert-butoxide (1.12 g, 10.0 mmol) was added in one portion to a solution of N-acetyl-3-(2-fluorophenyl)imidazolidine-2,4-dione (2.36 g, 10.0 mmol) and cyclohexanecarboxaldehyde (1.23 g, 11.0 mmol) in DMF (10 mL) at 0° C. The solution was allowed to warm to RT overnight with stirring, then diluted with water and extracted with ethyl acetate. The combined extracts were washed with brine (saturated), dried (over MgSO4), filtered and concentrated. The crude product was recrystallized from hexane/ethyl acetate to give 5-cyclohexylmethylene-3-(2-fluorophenyl)imidazolidine-2,4-dione, as a white solid.

1. extractionextracted with ethyl acetate
2. washThe combined extracts were washed with brine (saturated)
3. dry with materialdried (over MgSO4)
4. filtrationfiltered
5. concentrationconcentrated
6. customThe crude product was recrystallized from hexane/ethyl acetate