HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 70360497, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 21-Acetoxy-6alpha-methyl-17-propionyloxy-11beta-trifluoroacetoxy-4-pregnene-3,20-dione | HCID 70360393 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 70360497 | HCID 70360497 | 72.1% |
Reaction Steps
2.0 g of 21-acetoxy-6α-methyl-17-propionyloxy-11β-trifluoroacetoxy-4-pregnene-3,20-dione is agitated in 50 ml of methanol and 2.5 ml of triethylamine for 4 hours at room temperature. The crude product is purified on 300 g of silica gel with a methylene chloride-acetone gradient (0-15% acetone), thus isolating 1.2 g of 21-acetoxy-11β-hydroxy-6α-methyl-17-propionyloxy-4-pregnene-3,20-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04912098 |
| Source dataset | uspto-grants-1990_03 |
| ORD ID | ord-496d16b195c04c45ba10262b4aea2399 |
| Source note | uspto-grants-1990_03 |