HRID1165745

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

结构：CCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](OC(=O)C(F)(F)F)C[C@@]21C

HCID70360393

未命名化合物

PRODUCTS

生成物

结构：CCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

HCID70360497

未命名化合物

收率 72.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

2.0 g of 21-acetoxy-6α-methyl-17-propionyloxy-11β-trifluoroacetoxy-4-pregnene-3,20-dione is agitated in 50 ml of methanol and 2.5 ml of triethylamine for 4 hours at room temperature. The crude product is purified on 300 g of silica gel with a methylene chloride-acetone gradient (0-15% acetone), thus isolating 1.2 g of 21-acetoxy-11β-hydroxy-6α-methyl-17-propionyloxy-4-pregnene-3,20-dione.

WORKUP

后处理

customThe crude product is purified on 300 g of silica gel with a methylene chloride-acetone gradient (0-15% acetone)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-496d16b195c04c45ba10262b4aea2399
来源数据集: uspto-grants-1990_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04912098
来源说明: uspto-grants-1990_03

反应 SMILES

[C:1]([O:4][CH2:5][C:6](=[O:40])[C@:7]1([O:35][C:36](=[O:39])[CH2:37][CH3:38])[C@:24]2([CH3:25])[C@H:10]([C@H:11]3[C@H:21]([C@@H:22]([O:26]C(=O)C(F)(F)F)[CH2:23]2)[C@:19]2([CH3:20])[C:14](=[CH:15][C:16](=[O:33])[CH2:17][CH2:18]2)[C@@H:13]([CH3:34])[CH2:12]3)[CH2:9][CH2:8]1)(=[O:3])[CH3:2].C(N(CC)CC)C>CO>[C:1]([O:4][CH2:5][C:6](=[O:40])[C@:7]1([O:35][C:36](=[O:39])[CH2:37][CH3:38])[C@:24]2([CH3:25])[C@H:10]([C@H:11]3[C@H:21]([C@@H:22]([OH:26])[CH2:23]2)[C@:19]2([CH3:20])[C:14](=[CH:15][C:16](=[O:33])[CH2:17][CH2:18]2)[C@@H:13]([CH3:34])[CH2:12]3)[CH2:9][CH2:8]1)(=[O:3])[CH3:2]