Hydrochloric Acid → HCID 178448716, compound

HRID 1165775Notes

Reaction equation

HRID 1165775 reaction equation
C([NH:4][C:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH3:17])[C:10](=[O:18])[N:9]([CH2:19][CH2:20][CH2:21][CH3:22])[C:8]=2[NH:7][N:6]=1)(=O)C.[OH-].[Na+].Cl>C(O)C.O>[NH2:4][C:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH3:17])[C:10](=[O:18])[N:9]([CH2:19][CH2:20][CH2:21][CH3:22])[C:8]=2[NH:7][N:6]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178448714HCID 178448714, compound

Product 1

HCID 178448716HCID 178448716, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

3-Acetylamino-7-butyl-5-propylpyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione(10 g) was heated under reflux for 5 hours in 80% ethanol(100 ml) containing sodium hydroxide (2 g). The reaction mixture was concentrated to give crystals. The crystals were suspended in water(100 ml), to which was added 6N-HCl to make it weakly acid to afford colorless crystals(8 g,93%),m.p. 209°-211° C.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customto give crystals

Sources & evidence

ORD record
ord-e9eb5aecbc24495ab74c72921ffcb095
Source dataset
uspto-grants-1990_03
Patent number
US04912104

Reaction notes

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