反应详情

A mixture of 4 parts of 2-[4-[(4-chlorophenyl)cyanomethyl]-3-methoxyphenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile, 24 parts of concentrated hydrochloric acid and 40 parts of acetic acid is stirred and refluxed for 3 hours. The reaction mixture is evaporated in vacuo and the residue is stirred in water. The product is extracted with a mixture of trichloromethane and methanol (90:10 by volume). The extract is dried, filtered and evaporated, yielding 2-[4-[(4-chlorophenyl)cyanomethyl]-3-methoxyphenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carboxylic acid.

1. temperaturerefluxed for 3 hours
2. customThe reaction mixture is evaporated in vacuo
3. stirringthe residue is stirred in water
4. extractionThe product is extracted with a mixture of trichloromethane and methanol (90:10 by volume)
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated