反应详情

To a solution of 3,5-diaminobenzoic acid (6.1 g) in pyridine (80 ml) is added dropwise methoxyacetyl chloride (8.0 ml) at room temperature, and the mixture is stirred for 2 hours as it stands. From the reaction mixture, pyridine is distilled off under reduced pressure. To the residue is added 1N hydrochloric acid, and the resulting solid substance is separated by filtration and washed with water. The resulting crude crystals are recrystallized from ethanol to give the title compound (8.0 g) having the following physical properties.

1. distillationFrom the reaction mixture, pyridine is distilled off under reduced pressure
2. additionTo the residue is added 1N hydrochloric acid
3. customthe resulting solid substance is separated by filtration
4. washwashed with water
5. customThe resulting crude crystals are recrystallized from ethanol