HCID 178523902, compound → HCID 178512140, compound

Participants

Reaction Steps

0.8 g (1.5 mmol) of N1 -benzoyl-N2 -[3-(3,4-dichlorophenyl)-3-(pyridin-2-yl)propyl]-N3 -[3-(1H-imidazol-4-yl)propyl]-guanidine are heated under reflux in 40 ml of 20% hydrochloric acid for 10 hours. The hydrochloric acid solution is then extracted three times with ether, evaporated to dryness under vacuum and dried in a high vacuum. 0.74 g (91%) of the trihydrochloride is left behind as a hygroscopic, amorphous solid.

Provenance & Evidence