HCID 178523902, compound → HCID 178512140, compound

HRID 1165913Notes

Reaction equation

HRID 1165913 reaction equation
C([NH:9][C:10]([NH:29][CH2:30][CH2:31][CH2:32][C:33]1[N:34]=[CH:35][NH:36][CH:37]=1)=[N:11][CH2:12][CH2:13][CH:14]([C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)(=O)C1C=CC=CC=1>Cl>[Cl:28][C:23]1[CH:22]=[C:21]([CH:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:13][CH2:12][NH:11][C:10]([NH2:9])=[N:29][CH2:30][CH2:31][CH2:32][C:33]2[N:34]=[CH:35][NH:36][CH:37]=2)[CH:26]=[CH:25][C:24]=1[Cl:27]

Participants

3

Reactant 1

HCID 178523902HCID 178523902, compound

Product 1

HCID 178512140HCID 178512140, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

0.8 g (1.5 mmol) of N1 -benzoyl-N2 -[3-(3,4-dichlorophenyl)-3-(pyridin-2-yl)propyl]-N3 -[3-(1H-imidazol-4-yl)propyl]-guanidine are heated under reflux in 40 ml of 20% hydrochloric acid for 10 hours. The hydrochloric acid solution is then extracted three times with ether, evaporated to dryness under vacuum and dried in a high vacuum. 0.74 g (91%) of the trihydrochloride is left behind as a hygroscopic, amorphous solid.

Workup

  1. extractionThe hydrochloric acid solution is then extracted three times with ether
  2. customevaporated to dryness under vacuum
  3. customdried in a high vacuum
  4. wait0.74 g (91%) of the trihydrochloride is left behind as a hygroscopic, amorphous solid

Sources & evidence

ORD record
ord-e563553950294aa29e5653aecd2c9a00
Source dataset
uspto-grants-1990_03
Patent number
US04912119

Reaction notes

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