反应详情

A mixture of 1.71 g (0.005 mole) of 1-{1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl}-4-piperidinamine, 0.57 g (0.005 mole) of 2-chloropyrimidine, 0.43 g (0.052 mole) of sodium bicarbonate and 19 ml of ethanol is brought to reflux temperature for 2 days and 2 nights. The mixture is evaporated to dryness, and water and 2N sodium hydroxide are added. The product is taken up with methylene chloride, decanted and washed with water. The product is chromatographed on a silica column (eluent: dichloromethane/methanol, 47:3).

1. temperatureto reflux temperature for 2 days
2. custom2 nights
3. customThe mixture is evaporated to dryness, and water and 2N sodium hydroxide
4. additionare added
5. customdecanted
6. washwashed with water
7. customThe product is chromatographed on a silica column (eluent: dichloromethane/methanol, 47:3)