反应详情

温度

0 °C

To a dry flask was added aluminum trichloride (58 mg, 0.435 mmole) and benzene (3 ml). While stirring under argon, (cis)-1-benzoyl-4-tosyloxy-L-proline (50 mg, 0.128 mmole) was added. After further stirring overnight, the reaction was cooled to 0° C. and quenched with 1N HCl. The resulting mixture was extracted with ethyl acetate and the organic extracts were washed with brine, dried, and concentrated in vacuo. The residue consisted of:

1. stirringAfter further stirring overnight
2. customquenched with 1N HCl
3. extractionThe resulting mixture was extracted with ethyl acetate
4. washthe organic extracts were washed with brine
5. customdried
6. concentrationconcentrated in vacuo