Aziridine, 1-acetyl- → HCID 19861526, compound

HRID 1165986Notes

Reaction equation

HRID 1165986 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([CH3:11])[CH:5]=1)[CH3:2].[C:12]([N:15]1[CH2:17][CH2:16]1)(=[O:14])[CH3:13]>CO>[C:12]([NH:15][CH2:17][CH2:16][N:3]([CH2:1][CH3:2])[C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([CH3:11])[CH:5]=1)(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 9994Aziridine, 1-acetyl-HCID 19861524HCID 19861524, compound

Product 1

HCID 19861526HCID 19861526, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7.66 g (50 mMol) N-ethyl-4-fluoro-3-methyl-aniline and 4.68 g (55 mMol) N-acetylaziridine are refluxed in 100 ml methanol (abs.) for 15 hours. Then the reaction mixture is evaporated on a rotary evaporator and the residue is digested with diisopropylether. The solid thus obtained is filtered with suction, washed with diisopropylether and dried.

Workup

  1. customThen the reaction mixture is evaporated on a rotary evaporator
  2. customThe solid thus obtained
  3. filtrationis filtered with suction
  4. washwashed with diisopropylether
  5. customdried

Sources & evidence

ORD record
ord-77d165d9394849129772a6dccf61dd0e
Source dataset
uspto-grants-1990_03
Patent number
US04912258

Reaction notes

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