Ammonia → 5-Chloro-2-methoxybenzene-1-sulfonamide

HRID 11661Notes

Reaction equation

HRID 11661 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH3:14]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8]([NH2:14])(=[O:10])=[O:9])[CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27342725-Chloro-2-methoxybenzene-1-sulfonyl chloride

Product 1

HCID 132102965-Chloro-2-methoxybenzene-1-sulfonamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 5-chloro-2-methoxybenzene sulfonyl chloride (1.0 g, 4.15 mmol) in tetrahydrofuran (10 mL) was bubbled ammonia gas until saturated. The reaction was stirred overnight. The white solid that precipitated out of solution was collected by filtration and washed with dichloromethane to give the title compound (0.52 g).

Workup

  1. customThe white solid that precipitated out of solution
  2. filtrationwas collected by filtration
  3. washwashed with dichloromethane

Sources & evidence

ORD record
ord-f40b87c7e96a4cb98fe793f02a60727f
Source dataset
uspto-grants-2006_08
Patent number
US07098212B2

Reaction notes

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