HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl 2-(4-Chlorobenzoylamino)-3,4,5-trimethoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Chlorobenzoyl chloride | HCID 8501 | — |
| Reactant | Methyl 3,4,5-trimethoxyanthranilate | HCID 78735 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 2-(4-Chlorobenzoylamino)-3,4,5-trimethoxybenzoate | HCID 15406018 | — |
Reaction Steps
A solution of 20.3 g of 4-chlorobenzoyl chloride in 60 ml of THF was added dropwise to the solution of 25.3 g of methyl 2-amino-3,4,5-trimethoxybenzoate and 16 ml of triethylamine in 100 ml of THF. The mixture was refluxed for 1 hour (h), cooled in an ice bath and filtered. After concentration, a colorless residue remained. Yield: 34.1 g. Melting point (m.p.): 116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06613772B1 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-ccaf1e90c0594ea9894e2dd553034cc7 |
| Source note | uspto-grants-2003_09 |