反应详情

A solution of 20.3 g of 4-chlorobenzoyl chloride in 60 ml of THF was added dropwise to the solution of 25.3 g of methyl 2-amino-3,4,5-trimethoxybenzoate and 16 ml of triethylamine in 100 ml of THF. The mixture was refluxed for 1 hour (h), cooled in an ice bath and filtered. After concentration, a colorless residue remained. Yield: 34.1 g. Melting point (m.p.): 116° C.

1. temperatureThe mixture was refluxed for 1 hour (h)
2. temperaturecooled in an ice bath
3. filtrationfiltered
4. concentrationAfter concentration
5. custom116° C.