Ammonia → HCID 178486767, compound

HRID 1166146Notes

Reaction equation

HRID 1166146 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([NH:8][C:9]2[C:18]([O:19][CH3:20])=[C:17]([O:21][CH3:22])[C:16]([O:23][CH3:24])=[CH:15][C:10]=2[C:11](OC)=[O:12])=O)=[CH:4][CH:3]=1.[NH3:27]>CO>[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]2[N:27]=[C:11]([OH:12])[C:10]3[C:9](=[C:18]([O:19][CH3:20])[C:17]([O:21][CH3:22])=[C:16]([O:23][CH3:24])[CH:15]=3)[N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 15406018Methyl 2-(4-Chlorobenzoylamino)-3,4,5-trimethoxybenzoate

Product 1

HCID 178486767HCID 178486767, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

A suspension of 28.5 g of methyl 2-(4-chlorobenzoylamino)-3,4,5-trimethoxybenzoate in 200 ml of methanol was treated with 150 ml of liquid ammonia and heated at 100° C. for 5 h in an autoclave. On cooling, a precipitate deposited, which was filtered off with suction and dried under reduced pressure. Yield: 25 g. M.p.: 289° C.

Workup

  1. temperatureOn cooling
  2. filtrationwhich was filtered off with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-59b237c834a84dd6a45d0f96286e6094
Source dataset
uspto-grants-2003_09
Patent number
US06613772B1

Reaction notes

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