Phosphorus oxychloride → 2-(4-Chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline

HRID 1166147Notes

Reaction equation

HRID 1166147 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](O)[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:27])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([Cl:27])[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178486767HCID 178486767, compound

Product 1

HCID 117834712-(4-Chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline

Procedure

18.2 g of 2-(4-chlorophenyl)-hydroxy-6,7,8-trimethoxyquinazoline were heated at 100° C. for 3 h in 120 ml of phosphorus oxychloride. The excess phosphorus oxychloride was distilled off and the oily residue was stirred with ice water. The solid was filtered off with suction and dried under reduced pressure. Yield: 15.0 g. M.p.: 159° C.

Workup

  1. distillationThe excess phosphorus oxychloride was distilled off
  2. filtrationThe solid was filtered off with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-f7ab9f2dd19e434aa7fb150c69033950
Source dataset
uspto-grants-2003_09
Patent number
US06613772B1

Reaction notes

Loading…