反应详情

21.3 g of 2-(4-chlorobenzoylamino)-4,5-dimethoxybenzamide were heated at 100° C. for 2 h in 250 ml of 10% strength sodium hydroxide solution. The starting compound gradually went into solution in the course of this and a little later a precipitate deposited again. The mixture was diluted with 500 ml of water and adjusted to pH=4 using concentrated hydrochloric acid. After stirring for a further 2 h, the solid was filtered off with suction, washed with plenty of water and dried at 40° C. under reduced pressure. Yield: 19.0 g. M.p.: 329° C.

1. filtrationthe solid was filtered off with suction
2. washwashed with plenty of water
3. customdried at 40° C. under reduced pressure