Hydrochloric Acid → HCID 178486782, compound

HRID 1166150Notes

Reaction equation

HRID 1166150 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([NH:8][C:9]2[CH:17]=[C:16]([O:18][CH3:19])[C:15]([O:20][CH3:21])=[CH:14][C:10]=2[C:11]([NH2:13])=[O:12])=O)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>O>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[N:13]=[C:11]([OH:12])[C:10]3[C:9](=[CH:17][C:16]([O:18][CH3:19])=[C:15]([O:20][CH3:21])[CH:14]=3)[N:8]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 229974052-(4-Chlorobenzoylamino)-4,5-dimethoxybenzamide

Product 1

HCID 178486782HCID 178486782, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

21.3 g of 2-(4-chlorobenzoylamino)-4,5-dimethoxybenzamide were heated at 100° C. for 2 h in 250 ml of 10% strength sodium hydroxide solution. The starting compound gradually went into solution in the course of this and a little later a precipitate deposited again. The mixture was diluted with 500 ml of water and adjusted to pH=4 using concentrated hydrochloric acid. After stirring for a further 2 h, the solid was filtered off with suction, washed with plenty of water and dried at 40° C. under reduced pressure. Yield: 19.0 g. M.p.: 329° C.

Workup

  1. filtrationthe solid was filtered off with suction
  2. washwashed with plenty of water
  3. customdried at 40° C. under reduced pressure

Sources & evidence

ORD record
ord-e49a9a2170354beba6d199347a07ed79
Source dataset
uspto-grants-2003_09
Patent number
US06613772B1

Reaction notes

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