反应详情

Crude 4-hydroxy-6-phenylpyrimidine (3.65 g) was heated to reflux with phosphoryl chloride (40 ml) for 90 minutes. The reaction mixture was cooled and then concentrated under reduced pressure to afford a brown solid. The brown solid was partitioned between water and ether and the combined ether extracts washed with brine, dried and evaporated to give 4-chloro-6-phenylpyrimidine (2.18 g, 93.5% pure by GC analysis) as a yellow solid which was used directly in the next stage.

1. temperatureThe reaction mixture was cooled
2. concentrationconcentrated under reduced pressure
3. customto afford a brown solid
4. customThe brown solid was partitioned between water and ether
5. washthe combined ether extracts washed with brine
6. customdried
7. customevaporated