Phosphorus oxychloride → HCID 22997479, compound

HRID 1166176Notes

Reaction equation

HRID 1166176 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4](O)[C:5]2[C:6](=[C:8]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=3[Cl:19])[N:9]([CH3:11])[N:10]=2)[N:7]=1.P(Cl)(Cl)([Cl:23])=O>>[CH3:1][C:2]1[CH:3]=[C:4]([Cl:23])[C:5]2[C:6](=[C:8]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=3[Cl:19])[N:9]([CH3:11])[N:10]=2)[N:7]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178428912HCID 178428912, compound

Product 1

HCID 22997479HCID 22997479, compound

Procedure

Intermediate (4) (400 mg) was suspended in phosphorous oxychloride (2 ml) and refluxed for 2 hours. The reaction mixture was concentrated, yielding 5-methyl-7-chloro-2-methyl-3-(2,4-dichlorophenyl)pyrazolo[4,3-b]pyridine (intermediate 5).

Workup

  1. temperaturerefluxed for 2 hours
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-a88505515f8848628b54fdcf92bb94d4
Source dataset
uspto-grants-2003_09
Patent number
US06613777B1

Reaction notes

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