Hydrochloric Acid → HCID 22997659, compound

HRID 1166217Notes

Reaction equation

HRID 1166217 reaction equation
C([O:3][C:4](=[O:14])[C:5]([C:7]1[CH:11]=[C:10]([Br:12])[S:9][C:8]=1[Br:13])=[O:6])C.Cl>CC(C)=O.O>[Br:13][C:8]1[S:9][C:10]([Br:12])=[CH:11][C:7]=1[C:5](=[O:6])[C:4]([OH:14])=[O:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 61615517HCID 61615517, compound

Product 1

HCID 22997659HCID 22997659, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent2×

Procedure

(2,5-Dibromothiophen-3-yl)-oxo-acetic acid ethyl ester (1.71 g, 5.0 mmol) was dissolved in 15 ml acetone and 2 ml water, then treated with 15 ml concentrated HCl at reflux for 2 hours. The reaction mixture was then poured into 100 ml water, and extracted into 100 ml of dichloromethane. The organic layer was dried over Na2SO4 and concentrated under vacuum to yield crude (2,5-dibromothiophen-3-yl)-oxo-acetic acid which was used without further purification.

Workup

  1. temperatureat reflux for 2 hours
  2. extractionextracted into 100 ml of dichloromethane
  3. dry with materialThe organic layer was dried over Na2SO4
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-46db5f57fb464f6493ace42e3a92b7dc
Source dataset
uspto-grants-2003_09
Patent number
US06613786B2

Reaction notes

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