反应详情

A solution of 4-fluoro-2-nitroanisole (20.5 g, 120 mmol) in ethyl acetate (100 ml) was hydrogenated in a Parr shaker apparatus with 10% Pd on carbon (2 g) until a stable pressure reading was obtained. The reaction was filtered through Celite and concentrated under vacuum to an oil. The 4-fluoro-2-aminoanisole thus obtained (16.14 g, 96%) was used in the next step.

1. customwas obtained
2. filtrationThe reaction was filtered through Celite
3. concentrationconcentrated under vacuum to an oil