Hydrochloric Acid → HCID 22997343, compound

HRID 1166433Notes

Reaction equation

HRID 1166433 reaction equation
[ClH:1].Cl.C(OC([N:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]([C:28]3[CH:33]=[CH:32][C:31]([O:34][C:35]([N:37]4[CH2:42][CH2:41][N:40](C(OC(C)(C)C)=O)[CH2:39][CH2:38]4)=[O:36])=[CH:30][CH:29]=3)([CH3:27])[CH3:26])=[CH:21][CH:20]=2)=[O:17])[CH2:12][CH2:11]1)=O)(C)(C)C.Cl>O1CCOCC1.C1(C)C=CC=CC=1>[ClH:1].[ClH:1].[N:13]1([C:16]([O:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]([C:28]3[CH:29]=[CH:30][C:31]([O:34][C:35]([N:37]4[CH2:38][CH2:39][NH:40][CH2:41][CH2:42]4)=[O:36])=[CH:32][CH:33]=3)([CH3:27])[CH3:26])=[CH:21][CH:20]=2)=[O:17])[CH2:12][CH2:11][NH:10][CH2:15][CH2:14]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22997358HCID 22997358, compound

Product 1

HCID 22997343HCID 22997343, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 312751,4-DioxaneSolvent2×

Procedure

8.3 g of 2,2-bis[4-(4-tert-butoxycarbonyl-1-piperazinylcarbonyloxy)phenyl]propane dihydrochloride are dissolved in 50 ml of abs. dioxane, and 9.5 ml of an approx. 20% solution of hydrogen chloride in dioxane are added to this solution while stirring. The mixture is stirred overnight, after which it is diluted with toluene and the precipitate is filtered off with suction. After drying in vacuo, 5.7 g of the title compound, having a m.p. of from 200° C. (decomposition), are obtained.

Workup

  1. stirringThe mixture is stirred overnight
  2. filtrationthe precipitate is filtered off with suction
  3. dry with materialAfter drying in vacuo, 5.7 g of the title compound
  4. customare obtained

Sources & evidence

ORD record
ord-9921e0f126bd42e39794f3f5e9bdebba
Source dataset
uspto-grants-2003_09
Patent number
US06613769B1

Reaction notes

Loading…