反应详情

Acetyl chloride (0.67 g) was added to a pyridine solution (15 ml) of 2-aminomethyl-6-methoxytetralin hydrochloride (1.5 g; obtained in Reference Example 11), and the reaction mixture was stirred at room temperature for 16 hours, to which was added ethyl acetate. The organic layer was washed with 1 N hydrochloric acid and a saturated aqueous sodium bicarbonate solution, then dried, and concentrated. The resulting crude crystals were recrystallized from ethyl acetate-diisopropyl ether to obtain the entitled compound (960 mg).

1. washThe organic layer was washed with 1 N hydrochloric acid
2. dry with materiala saturated aqueous sodium bicarbonate solution, then dried
3. concentrationconcentrated
4. customThe resulting crude crystals were recrystallized from ethyl acetate-diisopropyl ether