HCID 22998584, compound → HCID 22998664, compound

HRID 1166528Notes

Reaction equation

HRID 1166528 reaction equation
[ClH:1].Cl.[CH2:3]([N:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([O:27]C)[CH:23]=3)[CH2:18]2)[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>Cl>[ClH:1].[ClH:1].[CH2:3]([N:10]1[CH2:11][CH2:12][N:13]([CH2:16][CH:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([OH:27])[CH:23]=3)[CH2:18]2)[CH2:14][CH2:15]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 22998584HCID 22998584, compound

Product 1

HCID 22998664HCID 22998664, compoundYield 127.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-(4-Benzylpiperazin-1-yl)methyl-6-methoxytetralin dihydrochloride (0.849 g) was added to conc. hydrochloric acid (20 ml) and the reaction mixture was heated under reflux for 6 hr and cooled. The resulting precipitate was collected and washed with ethanol, methanol, and diethyl ether to obtain the titled compound (0.523 g).

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux for 6 hr
  3. temperaturecooled
  4. customThe resulting precipitate was collected
  5. washwashed with ethanol, methanol, and diethyl ether

Sources & evidence

ORD record
ord-e2a992e9529a4d3f87eb604b6031af91
Source dataset
uspto-grants-2003_09
Patent number
US06613805B2

Reaction notes

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