反应详情

A solution of 4-(4-methoxy-3-methylphenyl)butyric acid (Compound 27, 24.0 g, 115.4 mmol) and 400 mL of methanesulfonic acid was stirred at room temperature under the argon atmosphere for 24 h, then poured into ice, extracted three times with ethyl acetate, washed with NaHCO3 1N, brine, dried over MgSO4, and filtered. The solvent was removed to give 19.2 g (88%) of the title compound as a dark brown solid.

1. additionpoured into ice
2. extractionextracted three times with ethyl acetate
3. washwashed with NaHCO3 1N, brine
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customThe solvent was removed