Acetaldehyde → HCID 22218336, compound

HRID 1166672Notes

Reaction equation

[CH2:1]([O:7][C:8]1[C:9]([NH:21][C:22]2[CH:32]=[CH:31][C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:24][CH:23]=2)=[CH:10][C:11]2[C:12]([CH3:20])=[CH:13][CH2:14][C:15]([CH3:19])([CH3:18])[C:16]=2[CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH:33](=O)[CH3:34]>>[CH2:33]([N:21]([C:9]1[C:8]([O:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])=[CH:17][C:16]2[C:15]([CH3:19])([CH3:18])[CH2:14][CH:13]=[C:12]([CH3:20])[C:11]=2[CH:10]=1)[C:22]1[CH:23]=[CH:24][C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:31][CH:32]=1)[CH3:34]

Participants

Reactant 2

HCID 177Acetaldehyde

HCID 69659124HCID 69659124, compound2×

Product 1

HCID 22218336HCID 22218336, compoundYield 100%

Procedure

Following General Procedure D ethyl 4-(3-n-hexyloxy-5,5,8-trimethyl-5,6-dihydronaphthalen-2-ylamino)benzoate (Compound 112, 0.03 g, 0.07 mmol) was reacted with acetaldehyde and the resulting crude product, residue was purified by flash column chromatography (hexane:ethyl acetate=4:1) to afford 0.030 g (100%) of the title compound as a yellow oil.

Workup

customthe resulting crude product, residue was purified by flash column chromatography (hexane:ethyl acetate=4:1)

Sources & evidence

ORD record: ord-85457c16a12f44a4a3f751a60f9ddd10
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06613917B1

Reaction notes

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