反应详情

The above 3-amino-4-hydroxybenzoic acid hydrazide (50 mg, 0.3 mmol) and the above 4-[2-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethoxy]-2-methoxybenzaldehyde (93 mg, 0.3 mmol) were dissolved in 2-propanol (4 ml) and the mixture was heated at reflux temperature for 16 hours. The cooled mixture was filtered and the precipitate was washed with 2-propanol (2×4 ml) and dried by suction to afford 66 mg (48%) of the title compound as a solid. M.p.: 162-164° C.

1. temperaturethe mixture was heated
2. temperatureat reflux temperature for 16 hours
3. filtrationThe cooled mixture was filtered
4. washthe precipitate was washed with 2-propanol (2×4 ml)
5. customdried by suction