HCID 11782744, compound → HCID 10871434, compound

Participants

Reaction Conditions

Reaction Steps

N-(4-Hydroxymethyl-3-methoxyphenyl)-2-(3-trifluoromethylphenyl)acetamide (0.7 g, 2 mmol) was dissolved in ethyl acetate (40 mL) and manganese dioxide (3 g, 34 mmol) was added. The reaction mixture was stirred at 20° C. for 3 hr and filtered. The organic phase was concentrated in vacuo to give crude N-(4-formyl-3-methoxyphenyl)-2-(3-trifluoromethylphenyl)acetamide that was used for the next step without further purification.

Provenance & Evidence