HCID 11782744, compound → HCID 10871434, compound

HRID 1166790Notes

Reaction equation

HRID 1166790 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:22])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)=[CH:5][C:4]=1[O:23][CH3:24]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:22])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=2)=[CH:5][C:4]=1[O:23][CH3:24])=[O:1]

Participants

4

Reactant 1

HCID 11782744HCID 11782744, compound

Product 1

HCID 10871434HCID 10871434, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
20 °C

Procedure

N-(4-Hydroxymethyl-3-methoxyphenyl)-2-(3-trifluoromethylphenyl)acetamide (0.7 g, 2 mmol) was dissolved in ethyl acetate (40 mL) and manganese dioxide (3 g, 34 mmol) was added. The reaction mixture was stirred at 20° C. for 3 hr and filtered. The organic phase was concentrated in vacuo to give crude N-(4-formyl-3-methoxyphenyl)-2-(3-trifluoromethylphenyl)acetamide that was used for the next step without further purification.

Workup

  1. filtrationfiltered
  2. concentrationThe organic phase was concentrated in vacuo

Sources & evidence

ORD record
ord-2b222276d569459496c2bef2e6cf9dc0
Source dataset
uspto-grants-2003_09
Patent number
US06613942B1

Reaction notes

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