反应详情

A mixture of methyl 5-bromo-1-naphthylcarboxylate (5.2 g, 19 mmol) and CuCN (3.4 g, 38 mmol) in 100 mL anhydrous DMF was refluxed overnight. After cooling the reaction to 70° C., a solution of NaCN (2 g) in 50 mL water was added to destroy the copper complex. Ethyl acetate was added and the two layers were separated. The organic layer was washed with brine, dried over MgSO4, and concentrated. Silica gel column chromatography using hexane/ethyl acetate (5/1) gave the product (3.8 g, 95%).

1. temperaturewas refluxed overnight
2. temperatureAfter cooling
3. customthe reaction to 70° C.
4. customto destroy the copper complex
5. additionEthyl acetate was added
6. customthe two layers were separated
7. washThe organic layer was washed with brine
8. dry with materialdried over MgSO4
9. concentrationconcentrated