Benzo(B)Thiophene → HCID 590313, compound

HRID 1166849Notes

Reaction equation

HRID 1166849 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li][C:11](C)([CH3:13])[CH3:12]>C1COCC1>[CH2:12]([C:5]1[S:1][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[CH:4]=1)[CH2:11][CH3:13]

Participants

4

Reactant 2

HCID 7221Benzo(B)ThiopheneHCID 178418306HCID 178418306, compound

Product 1

HCID 590313HCID 590313, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-n-Propylbenzo[b]thiophene was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles, 1.0 g), t-BuLi (1.7 M, 9.7 mmoles, 5.7 ml), n-bromopropane (9.7 mmoles, 0.88 ml) and THF (20 ml). 1.11 g (85%) of a light yellow liquid was isolated.

Sources & evidence

ORD record
ord-f9cdbbc7c6ae40a38bcb1b8b73629220
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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