(3-Methoxyphenyl)boronic acid → N-[5-(3-methoxyphenyl)thiophene-2-sulfonyl]pyrrole

HRID 1166883Notes

Reaction equation

HRID 1166883 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1.Br[C:13]1[S:17][C:16]([S:18]([N:21]2[CH:25]=[CH:24][CH:23]=[CH:22]2)(=[O:20])=[O:19])=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[S:17][C:16]([S:18]([N:21]3[CH:25]=[CH:24][CH:23]=[CH:22]3)(=[O:19])=[O:20])=[CH:15][CH:14]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 2734370(3-Methoxyphenyl)boronic acidHCID 23445587N-(5-bromothiophenesulfonyl)pyrrole

Product 1

HCID 22998523N-[5-(3-methoxyphenyl)thiophene-2-sulfonyl]pyrroleYield 93%

Procedure

N-[5-(3-methoxyphenyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C from 3-methoxyphenylboronic acid and N-(5-bromothiophene-2-sulfonyl)pyrrole in 93% yield. This was purified by recrystallization using hexane/ethyl acetate as solvent.

Workup

  1. customThis was purified by recrystallization

Sources & evidence

ORD record
ord-3fb080b7bc3847bfba90bacde221a72b
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

Loading…