Benzo(B)Thiophene → MLS002608206

HRID 1166916Notes

Reaction equation

HRID 1166916 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li]C(C)(C)C.[CH3:15][N:16]([CH3:25])[C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=1>C1COCC1>[S:1]1[C:5]([CH:21]([OH:22])[C:20]2[CH:19]=[CH:18][C:17]([N:16]([CH3:15])[CH3:25])=[CH:24][CH:23]=2)=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 7221Benzo(B)ThiopheneHCID 74794-(Dimethylamino)BenzaldehydeHCID 178418306HCID 178418306, compound

Product 1

HCID 237069MLS002608206

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

a-(2-benzo[b]thienyl)-4-dimethylaminobenzyl alcohol was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles, 1.0 g), t-BuLi (1.7 M, 8.9 mmoles, 5.3 ml), 4-dimethylaminobenzaldehyde (8.9 mmoles, 1.3 g) and THF (20 ml). The crude product (2.4 g) was carried forward without further purification.

Workup

  1. customThe crude product (2.4 g) was carried forward without further purification

Sources & evidence

ORD record
ord-3951f191fd0949d59f69ce3f01fed98f
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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