Sulfuryl chloride → HCID 22998448, compound

HRID 1166933Notes

Reaction equation

HRID 1166933 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[S:13][C:12]([S:14](N2C=CC=C2)(=[O:16])=[O:15])=[CH:11][CH:10]=1.[Na].S(Cl)([Cl:26])(=O)=O>>[Cl:26][S:14]([C:12]1[S:13][C:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])=[CH:10][CH:11]=1)(=[O:16])=[O:15]

Participants

4

Reactant 3

HCID 24648Sulfuryl chlorideHCID 5360545SodiumHCID 22998522HCID 22998522, compound

Product 1

HCID 22998448HCID 22998448, compoundYield 24%

Procedure

5-chlorosulfonyl-2-(2-methoxyphenyl)thiophene was prepared in the same manner as described in Example 65E from N-[5-(2-methoxyphenyl)thiophene-2-sulfonyl]pyrrole by hydrolysis of the sulfonamide to the sodium salt of sulfonic acid (83%) followed by conversion of the salt to the corresponding sulfonyl chloride, resulting in a 24% yield.

Workup

  1. customresulting in a 24% yield

Sources & evidence

ORD record
ord-036760f2f39c4b72b7827298918bd787
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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