(5-Ethylthiophen-2-yl)boronic acid → HCID 22998405, compound

HRID 1166972Notes

Reaction equation

HRID 1166972 reaction equation
[CH2:1]([C:3]1[S:4][C:5](B(O)O)=[CH:6][CH:7]=1)[CH3:2].Br[C:12]1[S:16][C:15]([S:17]([N:20]2[CH:24]=[CH:23][CH:22]=[CH:21]2)(=[O:19])=[O:18])=[CH:14][CH:13]=1>>[CH2:1]([C:3]1[S:4][C:5]([C:12]2[S:16][C:15]([S:17]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)(=[O:18])=[O:19])=[CH:14][CH:13]=2)=[CH:6][CH:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 19578941(5-Ethylthiophen-2-yl)boronic acidHCID 23445587N-(5-bromothiophenesulfonyl)pyrrole

Product 1

HCID 22998405HCID 22998405, compound

Procedure

N-[5-(5-ethyl-2-thienyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C from 2-ethylthiophene-5-boronic acid (411 mg, 2.64 mmol) and N-(5-bromothiophene-2-sulfonyl)pyrrole (700 mg, 2.39 mmol). Purification by column chromatography using 2% ethyl acetate/hexanes gave 630 mg of the pure product as a dark brown solid (90% yield).

Workup

  1. customPurification by column chromatography

Sources & evidence

ORD record
ord-4f4bdd93984e418b85b5f58a4f686d57
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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