HCID 10497709, compound → HCID 10715441, compound

HRID 1166993Notes

Reaction equation

HRID 1166993 reaction equation
[CH3:1][C:2]1[C:6]([CH3:7])=[C:5]([NH:8][S:9]([C:12]2[CH:16]=[CH:15][S:14][C:13]=2[C:17](N(C)OC)=[O:18])(=[O:11])=[O:10])[O:4][N:3]=1.[CH3:23][C:24]1[CH:32]=[CH:31][C:27]([CH2:28][Mg]Cl)=[CH:26][CH:25]=1>>[CH3:1][C:2]1[C:6]([CH3:7])=[C:5]([NH:8][S:9]([C:12]2[CH:16]=[CH:15][S:14][C:13]=2[C:17](=[O:18])[CH2:23][C:24]2[CH:32]=[CH:31][C:27]([CH3:28])=[CH:26][CH:25]=2)(=[O:10])=[O:11])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 10497709HCID 10497709, compoundHCID 178425359HCID 178425359, compound

Product 1

HCID 10715441HCID 10715441, compoundYield 65%

Procedure

N-(3,4-dimethyl-5-isoxazolyl)-2-(4-tolylacetyl)thiophene-3-sulfonamide was prepared, as described in Example 93B, by reacting N-(3,4-dimethyl-5-isoxazolyl)-2-[N-methoxy(methylaminocarbonyl)]thiophene-3-sulfonamide with 4-methylbenzylmagnesium chloride, resulting in a 65% yield, m.p. 95-100° C.

Workup

  1. customresulting in a 65% yield, m.p. 95-100° C.

Sources & evidence

ORD record
ord-8b5e9be6cb7049f7ae48faba994504ca
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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