Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

Participants

Reaction Steps

A solution of 4-(acryloxybutyloxycarbonyloxy)benzoic acid (2 mmol), N,N′-dicyclohexylcarbodiimide (2.2 mmol), 2,4-O-benzylidene-D-threitol (1.1 mmol; cf. Example 1c) and the catalyst 4-DMAP (0.1 mmol) in dichloromethane (5 ml) is stirred at room temperature until the reaction is complete, the N,N′-dicyclohexylurea which has been formed is filtered off and the solvent is removed under reduced pressure. The residue is finally purified by column chromatography and recrystallized from ethanol.

Provenance & Evidence