Acetyl chloride → HCID 11137766, compound

HRID 1167043Notes

Reaction equation

HRID 1167043 reaction equation
[CH2:1]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)[CH2:2][CH2:3][CH3:4].[C:10](Cl)(=[O:12])[CH3:11]>ClCCl>[C:10]([C:7]1[S:6][C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[CH:9][CH:8]=1)(=[O:12])[CH3:11]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 738182-n-Butylthiophene

Product 1

HCID 11137766HCID 11137766, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Butylthiophene (obtained by Friedel-Crafts acylation of thiophene with butyryl chloride followed by Wolf-Kizner reduction in accordance with EP-A 0 392 510) is acetylated with acetyl chloride in dichloromethane under AlCl3 catalysis. Customary work-up followed by purification by distillation affords 2-acetyl-5-butylthiophene, b.p. 92° C./0.8 mbar.

Workup

  1. distillationCustomary work-up followed by purification by distillation

Sources & evidence

ORD record
ord-d12b1327b5124b2a93205f498169957e
Source dataset
uspto-grants-2003_09
Patent number
US06616989B1

Reaction notes

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