HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 11137766, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 2-n-Butylthiophene | HCID 73818 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11137766 | HCID 11137766 | — |
Reaction Steps
2-Butylthiophene (obtained by Friedel-Crafts acylation of thiophene with butyryl chloride followed by Wolf-Kizner reduction in accordance with EP-A 0 392 510) is acetylated with acetyl chloride in dichloromethane under AlCl3 catalysis. Customary work-up followed by purification by distillation affords 2-acetyl-5-butylthiophene, b.p. 92° C./0.8 mbar.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06616989B1 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-d12b1327b5124b2a93205f498169957e |
| Source note | uspto-grants-2003_09 |