Water → HCID 135422991, compound

HRID 1167060Notes

Reaction equation

HRID 1167060 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[OH2:23]>>[OH2:23].[OH2:23].[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 962WaterHCID 135398745Olanzapine

Product 1

HCID 135422991HCID 135422991, compound

Conditions

Temperature
25 °C

Procedure

A 100 g sample of technical grade olanzapine (see Preparation 1) was suspended in water (500 mL). The mixture was stirred at about 25° C. for about 5 days. The product was isolated using vacuum filtration. The product was identified as Dihydrate D olanzapine using x-ray powder analysis. Yield: 100 g. TGA mass loss was 10.2%.

Workup

  1. customThe product was isolated
  2. filtrationvacuum filtration

Sources & evidence

ORD record
ord-6f73ab6aa390430086a5488d90ce7136
Source dataset
uspto-grants-2003_09
Patent number
US06617321B2

Reaction notes

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