Water → HCID 136360269, compound

HRID 1167062Notes

Reaction equation

HRID 1167062 reaction equation
O.[CH3:2][C:3]1[S:7][C:6]2[NH:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[N:15]=[C:16]([N:17]3[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]3)[C:5]=2[CH:4]=1.[CH3:24][CH:25]([CH2:27][CH2:28][CH2:29][C@H:30]([C@@H:32]1[C@:50]2([CH3:51])[C@H:35]([C@H:36]3[C@H:47]([CH2:48][CH2:49]2)[C@:45]2([CH3:46])[C:39]([CH2:40][C@H:41]([CH2:43][CH2:44]2)[OH:42])=[CH:38][CH2:37]3)[CH2:34][CH2:33]1)[CH3:31])[CH3:26]>C(Cl)Cl>[CH3:2][C:3]1[S:7][C:6]2[NH:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[N:15]=[C:16]([N:17]3[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]3)[C:5]=2[CH:4]=1.[CH3:26][CH:25]([CH2:27][CH2:28][CH2:29][C@H:30]([C@@H:32]1[C@:50]2([CH3:51])[C@H:35]([C@H:36]3[C@H:47]([CH2:48][CH2:49]2)[C@:45]2([CH3:46])[C:39]([CH2:40][C@H:41]([CH2:43][CH2:44]2)[OH:42])=[CH:38][CH2:37]3)[CH2:34][CH2:33]1)[CH3:31])[CH3:24]

Participants

5

Reactant 3

HCID 962WaterHCID 5997CholesterolHCID 135398745Olanzapine

Product 1

HCID 136360269HCID 136360269, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5 g (1%) polyvinyl alcohol (PVA) was added to 500 ml of deionized water. The solution was stirred with a magnetic stir bar and warmed for several hours until all of the PVA dissolved. The mixture was allowed to cool to room temperature. The solution was poured into a square plastic container and stirred with an overhead stirrer at 450 RPM. 1.2 g of olanzapine and 8.8 g of cholesterol was dissolved in 100 ml of methylene chloride. The PVA solution was added and the mixture was stirred for 18 hours.

Workup

  1. dissolutiondissolved
  2. additionThe solution was poured into a square plastic container
  3. stirringstirred with an overhead stirrer at 450 RPM
  4. stirringthe mixture was stirred for 18 hours

Sources & evidence

ORD record
ord-bb33436eaca34877a51988c41de3532b
Source dataset
uspto-grants-2003_09
Patent number
US06617321B2

Reaction notes

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