HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid → 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid | HCID 55251 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride | HCID 11066000 | — |
Reaction Steps
170 ml of oxalyl chloride are added dropwise at 0° C. to a suspension of 30 g (0.113 mol) of 4′-trifluoromethyl-biphenyl-2-carboxylic acid in 500 ml of dichloromethane and 0.2 ml of dimethylformamide. After the reaction has ended the reaction mixture is concentrated by distillation and the 4′-trifluoromethyl-biphenyl-2-carboxylic acid chloride is further reacted as a crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06617325B1 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-1235292331674decba5d42b1df772477 |
| Source note | uspto-grants-2003_09 |