HRID1167108

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)CC(C)(CCCN1CCC(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)CC1)c1ccccc1

HCID22995529

未命名化合物

PRODUCTS

生成物

结构：CC(CCCN1CCC(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)CC1)(CC(=O)O)c1ccccc1

HCID22995657

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

PROCEDURE

实验过程

A suspension of 1.5 g (0.0027 mol) of methyl 2-methyl-2-phenyl-5-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate in 60 ml of 6N hydrochloric acid is refluxed for 25 hours. After cooling the precipitate is filtered off and washed with water and ethyl acetate.

WORKUP

后处理

temperatureis refluxed for 25 hours
temperatureAfter cooling the precipitate
filtrationis filtered off
washwashed with water and ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-de572782bbc54cb987698d8e06304563
来源数据集: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06617325B1
来源说明: uspto-grants-2003_09

反应 SMILES

[CH3:1][C:2]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)([CH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]([C:20]2[C:21]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)=[O:19])[CH2:13][CH2:12]1)[CH2:3][C:4]([O:6]C)=[O:5]>Cl>[CH3:1][C:2]([C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)([CH2:8][CH2:9][CH2:10][N:11]1[CH2:12][CH2:13][CH:14]([NH:17][C:18]([C:20]2[C:21]([C:26]3[CH:27]=[CH:28][C:29]([C:32]([F:33])([F:34])[F:35])=[CH:30][CH:31]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)=[O:19])[CH2:15][CH2:16]1)[CH2:3][C:4]([OH:6])=[O:5]