反应详情

In a sulfonation flask, 5.7 g (0.023 mol) 3-cyano-2-(1,1-dipropoxymethylenamino)thiophene and 35 ml 1-aminopropane are heated at reflux temperature for 5 hours. Then the excess of 1-aminopropane is distilled off and the residue purified by column chromatography over silica gel (eluant: hexane/ethylacetate 1:1). Yield: 5.1 g of 3-propyl-2-propoxy-3H-thieno[2,3-d]pyrimidine-4-ylideneamine in the form of brownish crystals; m.p. 61-63° C.

1. temperatureat reflux temperature for 5 hours
2. distillationThen the excess of 1-aminopropane is distilled off
3. customthe residue purified by column chromatography over silica gel (eluant: hexane/ethylacetate 1:1)