Tetrahydrofuran → HCID 57955332, compound

HRID 116715Notes

Reaction equation

HRID 116715 reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[Li:37][CH3:38].[NH2:1][c:2]1[n:3][cH:4][n:5][n:6]2[c:7]1[c:8](-[c:16]1[cH:17][cH:18][c:19]([NH:22][C:23](=[O:24])[NH:25][c:26]3[c:27]([F:36])[cH:28][cH:29][c:30]([C:32]([F:33])([F:34])[F:35])[cH:31]3)[cH:20][cH:21]1)[c:9]([CH2:13][O:14][CH3:15])[c:10]2[CH:11]=[O:12]>>[NH2:1][c:2]1[n:3][cH:4][n:5][n:6]2[c:7]1[c:8](-[c:16]1[cH:17][cH:18][c:19]([NH:22][C:23](=[O:24])[NH:25][c:26]3[c:27]([F:36])[cH:28][cH:29][c:30]([C:32]([F:33])([F:34])[F:35])[cH:31]3)[cH:20][cH:21]1)[c:9]([CH2:13][O:14][CH3:15])[c:10]2[CH:11]([OH:12])[CH3:38]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 57955296N-{4-[4-amino-7-formyl-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl}-N'-[2-fluoro-5-(trifluoro-methyl)phenyl]ureaHCID 178418348HCID 178418348, compound

Product 1

HCID 57955332HCID 57955332, compound

Sources & evidence

ORD record
ord-f093446208bb422ba4013e694633e98b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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