Sodium Hydroxide → (R)-(+)-beta-Methylphenethylamine

HRID 1167218노트

반응식

HRID 1167218 반응식
C(O)(=O)C(CC(O)=O)O.[C:10]1([C@@H:16]([CH3:19])[CH2:17][NH2:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[OH-].[Na+]>C(Cl)Cl>[C:10]1([C@@H:16]([CH3:19])[CH2:17][NH2:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 21356831(2R)-2-phenylpropylamine malate

생성물 1

HCID 1547949(R)-(+)-beta-Methylphenethylamine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred suspension of (R)-2-phenyl-1-propylamine malate salt (24.3 g, 0.0601 mol, prepared directly above) in CH2Cl2 (200 mL) was added 1.0 N NaOH dropwise at room temperature. The organic phase was isolated, extracted with brine (1×125 mL), dried (Na2SO4), filtered and concentrated under reduced pressure to give 19 g (theory: 16.3 g) of (R)-2-phenyl-1-propylamine as a clear, colorless oil.

후처리

  1. customThe organic phase was isolated
  2. extractionextracted with brine (1×125 mL)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-506676c5c4cd4f07b5532b30ec996860
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06617351B1

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