反应详情

To a stirred suspension of (R)-2-phenyl-1-propylamine malate salt (24.3 g, 0.0601 mol, prepared directly above) in CH2Cl2 (200 mL) was added 1.0 N NaOH dropwise at room temperature. The organic phase was isolated, extracted with brine (1×125 mL), dried (Na2SO4), filtered and concentrated under reduced pressure to give 19 g (theory: 16.3 g) of (R)-2-phenyl-1-propylamine as a clear, colorless oil.

1. customThe organic phase was isolated
2. extractionextracted with brine (1×125 mL)
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure