Acetyl chloride → HCID 9838057, compound

HRID 1167229Notes

Reaction equation

HRID 1167229 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][C:9]([CH:12]([CH3:15])[CH2:13][NH2:14])=[CH:8][CH:7]=2)=[CH:2]1.[C:16](Cl)(=[O:18])[CH3:17]>O1CCCC1>[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][C:9]([CH:12]([CH3:15])[CH2:13][NH:14][C:16](=[O:18])[CH3:17])=[CH:8][CH:7]=2)=[CH:2]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 10727517HCID 10727517, compound

Product 1

HCID 9838057HCID 9838057, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1.0 mL (0.088 mmol) of a 0.088 M solution of 2-(4-(3-thienyl)phenyl)propylamine in tetrahydrofuran was added 37 mg (0.132 mmol) of piperidinylmethyl polystyrene. To the mixture was added 10.4 mg (0.132 mmol) of acetyl chloride and the mixture was shaken for 6 hours. To this mixture was added 0.15 g (0.3 mmol) of aminomethyl polystyrene and the vessel was shaken for 12 hours. The reaction mixture was filtered through a cotton plug and concentrated to afford the title compound. The NMR spectrum was consistent is with the proposed title structure.

Workup

  1. stirringthe vessel was shaken for 12 hours
  2. filtrationThe reaction mixture was filtered through a cotton plug
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-d3413c929956403ea5d37125902d9c16
Source dataset
uspto-grants-2003_09
Patent number
US06617351B1

Reaction notes

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