Hydrochloric Acid → HCID 69148574, compound

HRID 1167306Notes

Reaction equation

HRID 1167306 reaction equation
[ClH:1].[O:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[C:12]#[N:13])[CH2:5][CH2:4][CH2:3]1.[CH2:14]([OH:16])[CH3:15]>>[ClH:1].[CH2:14]([O:16][C:12]([C:10]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:11]=1[O:2][CH2:3][CH2:4][CH2:5]2)=[NH:13])[CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 702EthanolHCID 22996207HCID 22996207, compound

Product 1

HCID 69148574HCID 69148574, compoundYield 88%

Procedure

Hydrogen chloride gas was passed through a solution of chroman-8-carbonitrile (370 mg, 1.736 mmol) in anhydrous ethanol (15 mL) at 0° C. After 1 h, hydrogen chloride gas was stopped and the reaction vessel was sealed with a stopper. After stirring at room temperature for 1 d, the reaction vessel was cooled to 0° C. and the stopper was removed. The solvent was evaporated in vacuo to afford chroman-8-carboximidic acid ethyl ester hydrochloride (491 mg, 88%). It was used without further purification.

Workup

  1. customthe reaction vessel was sealed with a stopper
  2. temperaturethe reaction vessel was cooled to 0° C.
  3. customthe stopper was removed
  4. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-6e983ee174824b5888a2cc5261b76617
Source dataset
uspto-grants-2003_09
Patent number
US06617346B1

Reaction notes

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