反应详情

A mixture of 5-ethyl-2-iodophenol (1.0 g, 4 mmol), potassium carbonate (1.10 g, 8 mmol) and 2-iodopropane (0.80 mL, 8 mmol) was heated at reflux for 6 h. The reaction mixture was cooled to room temperature and water was added. The mixture was extracted with diethyl ether. The combined organic extracts were washed with brine and dried over anhydrous magnesium sulfate. The solid was then filtered off, and the filtrate was concentrated in vacuo. Purification of the residue by flash chromatography (Biotage system, KP-Sil™ 32-63 μm, 60 Å silica gel) eluting with hexanes, 5% ethyl acetate in hexanes yielded 4-ethyl-1-iodo-2-isopropoxy-benzene (0.93 g, 80%).

1. temperaturewas heated
2. temperatureat reflux for 6 h
3. extractionThe mixture was extracted with diethyl ether
4. washThe combined organic extracts were washed with brine
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationThe solid was then filtered off
7. concentrationthe filtrate was concentrated in vacuo
8. customPurification of the residue by flash chromatography (Biotage system, KP-Sil™ 32-63 μm, 60 Å silica gel)
9. washeluting with hexanes, 5% ethyl acetate in hexanes