反应详情

Hydrogen chloride gas was passed through a solution of 2-(2-dimethylamino-ethoxy)-4-methoxy-benzonitrile (200 mg, 0.908 mmol) in anhydrous ethanol (10 mL) at 0° C. After 45 min, hydrogen chloride gas was stopped and the reaction vessel was sealed with a septum. After stirring at room temperature for 3 d, the reaction vessel was cooled to 0° C. and the septum was removed. The solvent was removed in vacuo to afford ethyl 2-(2-dimethylamino-ethoxy)-4-methoxy-benzimidate hydrochloride as a pale-yellow foam (310 mg, 96%). It was used without further purification.

1. customthe reaction vessel was sealed with a septum
2. temperaturethe reaction vessel was cooled to 0° C.
3. customthe septum was removed
4. customThe solvent was removed in vacuo